Nanofiber-hydrogel composite–mediated angiogenesis for soft tissue reconstruction
نویسندگان
چکیده
منابع مشابه
Multilayer cell-seeded polymer nanofiber constructs for soft-tissue reconstruction.
IMPORTANCE Cell seeding throughout the thickness of a nanofiber construct allows for patient-specific implant alternatives with long-lasting effects, earlier integration, and reduced inflammation when compared with traditional implants. Cell seeding may improve implant integration with host tissue; however, the effect of cell seeding on thick nanofiber constructs has not been studied. OBJECTI...
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INTRODUCTION: Restoration of acquired, congenital, or age-related soft tissue defects using autologous or implantable materials can cause donor site morbidity, infection, device failure, and fibrosis. Injectable fillers are limited by variable resorption and fat grafting causes necrosis in large volumes. An alternative approach using the body’s regenerative capacity and an injectable synthetic ...
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PSRC Abstract Supplement P oter P rofs transection without repair. First, we evaluated the extensor digitorum longus (EDL) muscles of 15 adult wildtype C57BL/6 mice (n=3 per time point) at days 1, 3, 5, 7, and 14 after sciatic nerve injury. The uninjured EDL muscles served as the experimental controls. These muscles were harvested for immunostaining with CD68 (monocytes/ macrophages) and DAPI (...
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BACKGROUND Extended Soft tissue defect of leg including middle and distal parts always has been a challenge for many plastic surgeons and also a frustrated problem for patients and families. To introduce the use of the soleus muscle and reverse sural flaps as synchronous surgical treatment alternative of the leg bone exposure with large soft tissue defect, this study was conducted. METHODS T...
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Amyloid-like protein nanofibers were assembled in vitro using a recombinant protein fusion, with yeast Sup35 and human SSB/La proteins as assembly units, where the length of the nanofibers was mostly between 100 and 400 nm. The protein nanofibers, hereafter referred to as Sup35-based protein nanofiber probes (SuPNPs), were used to sensitively detect anti-SSB/La antibodies [Sjögren's syndrome (S...
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ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2019
ISSN: 1946-6234,1946-6242
DOI: 10.1126/scitranslmed.aau6210